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Figure 3 shows the timeline tracking major therapeutic milestones in HFpEF management, from early therapies (beta-blockers, angiotensin-converting enzyme inhibitors (ACEi)) to recent advances (sodium-glucose cotransporter-2 inhibitors (SGLT2i), semaglutide)

We used new-user design to mitigate prevalent user bias and confounding associated with the drug itself [40, 41]

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However, newer medications target multiple metabolic hormones: GLP-1 drugs (single-hormone): semaglutide medications like Wegovy and Ozempic Dual-agonist drugs: tirzepatide medications like Mounjaro and Zepbound (target GLP-1 and GIP receptors) Triple-agonist drugs: retatrutide (targets GLP-1, GIP and glucagon receptors) Researchers believe stimulating multiple hormone pathways may produce stronger effects on appetite, metabolism and energy expenditure

Being thorough and organized is key

A University College London kutati azt lltjk, hogy hsz szzalkkal cskkenti a szvroham, a szlts vagy ms szv- s rrendszeri megbetegeds hallos kimenetelnek kockzatt