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In addition, the authors noted that tirzepatide showed no meaningful benefit over semaglutide. Despite the widespread morbidity and mortality burden of HFpEF, current treatment options are limited, corresponding author Nils Krger, MD, with the division of pharmacoepidemiology and pharmacoeconomics at Brigham and Womens Hospital, said in a statement

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Without this level of analytical precision, pooled effect estimates will continue to obscure clinically actionable information

Body composition changesspecifically muscle versus fat lossare best tracked through periodic DEXA scans, bioimpedance analysis, or skilled clinical assessment rather than scale weight alone

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It is better to slow the dose escalation and stop the ondansetron as quickly as possible," he said