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For people who quit semaglutide because of unbearable nausea, bloating , or constipation , this is encouraging data suggesting they may tolerate tirzepatide better
2024;386:p
GLP-1 agonists offer a unique advantage: patients are motivated to continue the medication because of its visible metabolic benefits
In addition, there is the potential for an increased incidence of hypersensitivity reactions such as injection-site reactions

It is a 42-amino acid peptide secreted by the K-cells, present in high density in the duodenum and upper jejunum, following oral ingestion of nutrients such as glucose, amino acids, and long-chain fatty acids (Fig

Diabetologia 45 , 11111119 (2002)