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Consistent findings have shown that GLP-1R agonism promotes weight loss and improves glucose homeostasis in rodents, monkeys and humans (reviewed in Barrera et al., The anatomical distribution of the endogenous GLP-1 system GLP-1 is derived from the preproglucagon gene

For many individuals, the benefits of improved blood sugar control, cardiovascular risk reduction, or meaningful weight loss may outweigh potential gut-related risks

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When it comes to outcomes and safety measures in different age groups, an exploratory analysis of seven PIONEER trials was done

Shibata H, Itoh H

Plus, radiofrequency is generally safe for all skin types and tones