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Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

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Vitamin B12 is particularly important to monitor, as metformin is known to impair B12 absorption

doi: 10.1016/S0140-6736(21)00213-0 68 FriasJPDeenadayalanSErichsenLKnopFKLingvayIMacuraSet al

it does not predict exact medication response or replace medical evaluation

Manjunath Havalappa Dodamani is a Consultant Endocrinologist with specialized training in hormonal and metabolic disorders