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Once daily drugs caused larger reductions in hemoglobin A1c than twice daily agents, and weekly administration had an even bigger impact
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Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy

In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine
