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Over time, this inconsistency affected the results

470 In this study, researchers randomized 529 patients with heart failure with a preserved ejection fraction and body mass index (weight in kilograms in the square of the height in meters) 30 to receive once-weekly injections of semaglutide (2.4 mg) or placebo for 52 weeks

The reason is that as you lose weight, and as your metabolism changes, you may find that you need less thyroid hormone over time

Huberman recommends

But GLP ones being used in people who are not overweight, but they have PCOS because mechanistically, we know that roughly 70% of those with PCOS have insulin resistance

The most recent estimates are from 2016