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Recent research has discovered that metformin can inhibit FXR signaling by altering gut bacteria, leading to increased GLP-1 production and release in a way that does not depend on AMPK activation (Sun et al., 2018)

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Liu, J., Lee, J., Salazar Hernandez, M

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Inflamm Bowel Dis 21:287296 Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ et al (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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