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To further confirm the role of NLRP3 inflammasome in fibroblast activation, three different siRNAs were designed to knock down NLRP3 expression in fibroblasts

If constipation is your concern, gentler approaches like magnesium citrate, fiber supplements, and adequate hydration are far safer than stimulant laxatives

For comparison, the Wegovy trials reported nausea at approximately 44% and the Zepbound trials at approximately 28%

Cell Rep 27(11):3371-3384.e3

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