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17,18 In the authors experience, it is often possible to eliminate the sulfonylurea altogether, which can be advantageous in terms of avoiding hypoglycemia, minimizing the complexity of the diabetes regimen, and augmenting the weight loss benefits of the GLP-1 RA

Ethics declarations Conflict of Interest MH has received consultant fees from Alkermes, Inc

For decades, we relied on the magic of glycemic control and control of hypertension to turn the tide of worsening DKD, only to see some patients with decent HbA1Cs still suffer from a decline of kidney function

GLP-1R plays an important role in controlling blood sugar level by enhancing glucose-stimulated insulin secretion, glucose, lipid metabolism, and satiety

Lower risk generally supports greater long-term sustainability

By combining berberine (a plant alkaloid with metabolic effects) and ursodeoxycholate (a bile acid that enhances absorption), researchers created a novel therapy that targets more than just blood sugar
