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In isolated murine -cells, GLP-1 stimulates exocytosis of the insulin granules and this can be blocked by co-treatment of GLP-1 with the adenylate cyclase inhibitor MDL 12330A [508]
doi: 10.1371/journal.pone.0097554
The incretin effect is very brief because it remains active 12 min after its secretion and is then inactivated by the enzyme dipeptidylpeptidase-4 (DPP-4) [7]
GLP-1RAs stimulate insulin secretion in a glucose-dependent manner, therefore, reduce the risk of hypoglycemia
World Psychiatry 2023;22:116128
