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Until more long-term studies are done, the risk of thyroid tumors to humans is not known

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Tirzepatide is a dual GLP-1 and GIP receptor agonist that has demonstrated weight loss of 20-24% in clinical trials at maximum dose

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GLP-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and -cell proliferation

There appears to be a discrepancy in the assessment of the appropriate management of dysesthesia occurring after GLP-1R agonists exposure: spontaneous resolution despite treatment continuation in clinical trials versus resolution after treatment discontinuation in real-world practice, with positive rechallenge in some cases