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Youre not alone many patients report unexpected musculoskeletal discomfort as their bodies rapidly shed pounds

Weight loss is rarely linear, and factors such as water retention, hormonal fluctuations, muscle gain, and normal metabolic adaptation can temporarily slow progress

Tirzepatide population pharmacokinetics and exposure Schneck 19-study pooled popPK (CL/F 0.061 L/h, half-life 5.4 d, accumulation 1.7x, body-weight covariate +22% at 70 kg / -33% at 120 kg)

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For instance, if you typically take your dose on Monday and realize on Wednesday that you missed it, go ahead and take the missed dose on Wednesday