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Social media can be a great place to discover weight loss tips, healthy recipe ideas, fitness routines, and other wellness hacks

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If the food you do eat is lacking in nutrients, it may also be low in water content, says Amy Rothberg, MD, professor of medicine in the division of metabolism, endocrinology, and diabetes at the University of Michigan in Ann Arbor and director of Rewind, a virtual weight management and diabetes treatment program

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Mechanistically, GLP-1 signaling modulates immune and inflammatory pathways, regulates autophagy and pyroptosis, alleviates endoplasmic reticulum stress, and interacts with the gut microbiome

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Mechanistically, GLP-1R activation appears to downregulate TNF- production via 1-adrenergic, -opioid, and -opioid receptor pathways (Wong et al., 2024)

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Last reviewed: May 24, 2026 Last updated: May 24, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Semaglutide (Ozempic and Wegovy), along with other GLP-1 medications, works by mimicking a naturally occurring hormone in your body called glucagon-like peptide-1 (GLP-1)

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