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In vitro experiments proved that it reversed the phosphorylation status of IRS1, Akt, and GSK-3 and reduced beta-amyloid formation and tau hyperphosphorylation in the human neuroblastoma cell line, SH-SY5Y

Gastroenterology 2005

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Dulaglutide decreased the hyperphosphorylation of tau and NFs proteins through improving the PI3K/Akt/GSK3 signaling pathway, which may be related to its protective effects on impaired of AD-like learning and memory (150)

Full story via BioPharma Dive: #ClinicalTrials #DrugDevelopment #AIDrugDiscovery #SmallMolecules #Immunology #Neuroscience #BiopharmaInnovation #ClinicalResearch #LifeSciences #PrecisionMedicine To view or add a comment, sign in Zealand Pharma + OTR Therapeutics partner on metabolic disease therapeutics with $20M upfront + $2.5B biobucks - more biotech & pharma news below: Amgen's Uplizna (inebilizumab) wins FDA approval for generalized myasthenia gravis targeting CD19-positive B cells xcellbio + Culture Biosciences partner to advance cell therapy quality through AI and machine learning Eli Lilly and Company's retatrutide (triple hormone receptor agonist) achieves 26.6% weight loss in Ph3 obesity trial Aukera Therapeutics emerges from stealth with CHF 4.5M ($5.63M) funding for neurological RAPTOR inhibitor development ProLynx raises $70M Series A for longer-lasting obesity drugs with less frequent dosing European legislators agree on major pharma policy overhaul reducing drug exclusivity periods + strengthening supply chains For all the news, check out the full (free) TLDR Biotech newsletter here: ---------------------------------------- One skimmable email per day to keep up with biotech and pharma Sponsored today by Science 2 Sales - outsourced lead generation services hyperfocused on biotech and life sciences