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An early indication that this combination could be superior to single GLP-1R agonist administration was provided by Finan et al

Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis

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Where it works: Adipose tissue (fat cells): Reduces inflammation and may improve fat metabolism Pancreas: Works alongside GLP-1 to enhance insulin secretion Brain: May contribute to appetite regulation (research ongoing) Weight loss contribution: When GIP is added to GLP-1 (as in tirzepatide), weight loss increases from ~15% to ~22%