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The Clinical Science of Metabolic Adaptation and Tirzepatide Reaching the 12-week mark in your weight management journey often brings a shift in how your body responds to treatment

GLP-1 medications are typically prescribed for individuals who have a body mass index (BMI) of 30 or higher, or for those with a BMI of 27 or higher who also have at least one weight-related health condition, such as type 2 diabetes or high blood pressure

So they actively assign people to either the drug or the placebo to help control other possible causes

Common causes of GLP-1 stalls The physiology sets the stage

a Table is adapted from Montanya et al