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By week eight, the elevated baseline is fully established, and every side effect is proportionally more likely and more severe

If your side effects are mild but impact your quality of life, communicate these issues right away

Even in a caloric deficit, regular resistance exercise dramatically reduces the amount of lean mass lost

Water retention fluctuates

Some temporary weight fluctuation (1-3 pounds) is normal during the transition period as your body adjusts to the new medication

These effects are subtle enough that many people attribute them to diet changes, stress, or other factors rather than medication degradation