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HR = 0.90 (125)], even in those patients with previous heart failure (132134), suggesting that the increased risk with saxagliptin is not mechanistically related to the inhibition of DPP-4 per se , but the cause is still unexplained

As youll see below, the combination of formulary exclusion and private labels is creating an increasingly confusing and crowded biosimilar marketplace

Seek urgent medical advice if you experience: Severe, persistent upper abdominal pain (with or without vomiting), which could indicate pancreatitis Symptoms of gallbladder disease (pain in the right upper abdomen, especially after eating) Signs of dehydration or reduced kidney function if you've had vomiting or diarrhoea If you suspect any adverse effects from your medication, you can report them through the MHRA Yellow Card scheme

Any score greater than 8 kPA on VCTE should be referred to Hepatology for further assessment

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