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GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

There are several reasons to explain this limited beneficial effect on HbA1c (and also on body weight)

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In the LEADER study, acute gallbladder or biliary tract disease increased when liraglutide was used, and a recent meta-analysis reported an increased risk of cholelithiasis

For patients prioritizing weight loss, semaglutide is clearly superior

Each episode breaks down the neuroscience behind food patterns, cravings, and mindset shifts so you can finally understand why you get stuck, and what to do about it