naturally occurring glp-1 agonists Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 Drugs and Eating Disorders:

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doi: 10.1161/CIRCULATIONAHA.124.067676

Rather than opposing dopamine directly, they promote satiety, modifying the context in which dopaminergic learning occurs

The shorter half-life allows for more precise timing of medication cessation when clinically indicated [26]

Nonadherence was determined based on the date of treatment discontinuation with GLP1 RA or metformin, day 90 (index) if no further prescription than the initial was redeemed

Formulation also plays a role