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PEGylated GLP-1 exhibited a prolonged half-life and improved glycaemic control in diabetic mice

Articles were initially screened for relevance based on the content of their abstracts

Note that GLP-1 receptor agonists should not be used in combination with DPP-4 inhibitors (e.g., sitagliptin, linagliptin) as per NICE guidance

Expect to see oral doses in the hundreds of milligrams to achieve what injectable doses accomplish in single-digit milligrams

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Peptides like GLP-1 analogs (semaglutide), insulin-sensitizing peptides, and some growth hormonereleasing peptides are investigated