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In a now landmark study, Michael Nauck demonstrated that hyperglycaemic fasting glucose levels could be brought into the normal range by intravenous GLP-1 infusion in individuals with T2DM (16)
Administration of GLP-2-2G-XTEN resulted in a significant increase in small intestine weight and length as well as reduced inflammation scores and proinflammatory cytokines (Alters et al
We do not yet have decades of data on people without metabolic disease using GLP-1 drugs for many years

[DOI] [PubMed] [Google Scholar] 253.Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J

Abstract Glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that plays an important role in glucose homeostasis and treatment of type 2 diabetes
