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In medically suitable patients with type 2 diabetes, this helps support glucose-dependent insulin release, reduces inappropriate glucagon release, and improves overall blood-glucose and HbA1c control

Orforglipron is the first small molecule to act as an oral GLP-1 agonist"

Bray GA, Kim KK, Wilding JPH

[1] The oral formulation of semaglutide (Rybelsus) follows similar elimination kinetics to the injectable form despite the different route of administration

Heuvelman VD, Van Raalte DH, Smits MM

Exendin-4 alleviates retinal vascular leakage by protecting the blood-retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats