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Clinically, these therapies are prescribed for individuals with obesity or those who are overweight with associated health conditions such as diabetes, hypertension, or lipid disorders

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According to Research and Markets, the global GLP-1 market is estimated to grow from $62.2 billion to $157.5 billion by 2035, at a CAGR of 9.7%

Eating a low-fat dinner at least 3 hours before bed, limiting fluids in the last hour before sleep, and avoiding alcohol in the evening all help

This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits

However, these observational studies have inherent limitations, including potential residual confounding (as some registries lack complete data on important cancer risk factors like smoking), selection bias, and the challenge of detecting rare events