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Whilst not explored in detail in the latter project, we observed that the addition of a C-terminal acyl chain further influenced the ability of each ligand to recruit G proteins and -arrestins to the GLP-1R, highlighting this feature as a modifier of GLP-1R efficacy in its own right

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10.1186/s12933-017-0646-z 48 LeporeJ

26 GLP1 binds to and mediates the biological activation through the G proteincoupled receptor GLP1R

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GIP, glucosedependent insulinotropic polypeptide