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Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Meddens S.F.W., de Vlaming R., Bowers P., Burik C.A.P., Linnr R.K., Lee C., et al

An important concern associated with the development of GLP-1 Fc fusion products is their potential safety risk arising from the ability of the Fc fragment to trigger antibody-dependent cell-mediated (ADCC) cytotoxicity and complement-mediated cell lysis through Fc- receptor interactions