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While this additive effect might seem beneficial, unmonitored combination therapy can lead to dangerously low blood glucose levels

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In fasted states, the GLP-1 agonist Exendin-4 attenuates glucose-6-phosphatase and maintains glycogen synthase (GYS) activity but has no effect in PASK-deficient mice, whereas they already maintain an elevated level of expression of GYS [142]

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The effectiveness of weight-loss lifestyle interventions for improving fertility in women and men with overweight or obesity and infertility: a systematic review update of evidence from randomized controlled trials

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