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Therapeutic Advances in Endocrinology and Metabolism
Na V 1.8 was detected in a subset of postganglionic neurons in thoracic sympathetic ganglia in humans and mice, where p.R14L produced a gain-of-function profile that enhanced cholinergic responsiveness
Not all peptide systems share these properties, and some may fail due to genuine on-target toxicity that cannot be mitigated solely through pharmacologic engineering
