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[DOI] [PubMed] [Google Scholar] 182.Laux G., Berger S., Szecsenyi J., Kaufmann-Kolle P., Leutgeb R

Nonetheless, there is still some controversy on the in vivo involvement of FFAR2 and FFAR3 in GLP-1 modulation (301, 302), with some reports indicating that blockade of GPR43 in vitro releases GLP-1 (303) and others indicating different mechanisms of action, with FFAR2 releasing PYY from intestinal L-cells (81), while FFAR3 restricted to submucosal neuronal activity (295) despite its apparent expression by the majority of enteroendocrine cells (83)

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Across these trials, tesamorelin at 2 mg subcutaneously once daily produced a statistically significant reduction in visceral adipose tissue and waist circumference over 26 weeks, with 26-week extension phases showing that the visceral-fat improvement was maintained on continued treatment and, importantly, without adverse effects on blood glucose or lipid parameters in those analyses

#PharmaNews #HealthcareInnovation #PharmaStrategy #IndianPharma #PharmaUpdates #Harshal #PharmawithHJ #HJ To view or add a comment, sign in The Weight Loss Drug That's Making GLP-1s Look Like Yesterday's News While everyone's talking about Ozempic and Wegovy, there's a compound quietly outperforming them in clinical trials that most doctors haven't even heard of

The TRIUMPH-3 clinical trial for retatrutide began in April 2022 and enrolled adults with obesity who are at high risk for cardiovascular disease or heart disease