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Acknowledgements Graphical Abstract, Figure 1, and Figure 2 were created using Biorender

Patients with documented improvement more often experienced larger reductions in BMI compared with those with no change or worsening

Moreover, because adverse effects are more prevalent at higher GLP-1 RA doses, discontinuation of these medications might lead to a high likelihood of side-effects upon medication reinitiation or require reinitiation of therapy at lower doses followed by dose reescalation

Whether your goals are significant weight loss or weight maintenance, make this clear from the start

Stat Med (2013) 32(16):283749

Gastaldelli A, Abdul Ghani M, DeFronzo RA