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While these observations are supportive of GLP-1RA use in liver cirrhosis, prospective studies are needed to confirm this

Additionally, both semaglutide and tirzepatide showed promise in improving metabolic dysfunction-associated steatotic liver disease (MASLD), mitigating systemic inflammation, and contributing to improvements in liver-related outcomes, including steatosis resolution and fibrosis-related endpoints, in clinical trials

GLP-1 use has also been linked to a lower risk of developing 14 obesity-related cancers, suggesting a potential preventative effect 3

Lower scores are better , thus the authors considered this data as potential evidence supporting slowing of disease progression
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