glp 1 agonist moa Frontiers Current Insights, Advantages and Challenges
Description
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Food and Drug Administration (FDA-a)
It reduced pro-inflammatory cytokines (TNF-, IL-6, IL-1), chemokines, adhesion molecules and oxidative stress, while upregulating the expression of neurotrophic factors (neuritin and NGF) [11]
In addition to this endocrine action, the local inhibitory effect of DPP-4 inhibitors on GLP-1 degradation in the intestinal mucosa may contribute to favorable metabolic regulation by stimulating the autonomic afferent nervous system (10, 19)
Current evidence indicates protective effects against several malignancies (including colorectal, hepatic, and prostate cancers), whereas other studies suggest potential risks for specific cancer types, particularly thyroid cancer
Wegovy: side effects Wegovy and Contrave have some overlap in their potential side effects, such as nausea
