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As weight-loss drug popularity soars, more benefits and risks of the drugs are emerging.

However, there was progress in the UK where the government announced Scotland CardioMetabolic Impact Study (SCoMIS) , a pioneering Real-World study, which will provide Wegovy to between 3,000-5,000 people living with Obesity in Scotlands poorest areas free of charge during a three year study [11] Despite FDA phasing out enforcement discretion that allowed GLP-1 compounding during shortages - and setting May 2025 deadlines for compounding to cease - compounding has continued beyond this deadline [12]

Individualization is Key: The ADA strongly advocates tailoring HbA1c goals based on: Duration of diabetes Risk of hypoglycemia Life expectancy Comorbidities (cardiovascular disease, CKD) Patient preference and treatment burden Beyond HbA1c: Modern diabetes care increasingly integrates Continuous Glucose Monitoring (CGM) metrics such as Time in Range (TIR) alongside HbA1c

Explore GLP-1 insights, including trends in online prescriptions, increased fruit and vegetable consumption, and shopping intent among users.

The article explores how medications like semaglutide and tirzepatide, originally approved for diabetes and obesity, are increasingly being prescribed off-label to address underlying metabolic issues such as insulin resistance, weight gain, and hormonal []