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A well-designed network meta-analysis (NMA) of GLP-1 receptor agonists and SGLT2 inhibitors, which allows for direct comparisons among different medications, could enhance the ability to make multiple treatment efficacy comparisons and assess the potential superiority of specific interventions at various dosages [12]

56 These trials demonstrate that although orforglipron is safe and efficacious more longitudinal research is warranted to provide deeper insights into their efficacy, safety and tolerability before their potential incorporation in the pharmacological arsenal against T2DM or obesity

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This product is supplied as a dry powder and requires reconstitution before research use.

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