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Pearls There have been significant advances in the field of MCS/LVAD therapy since the first implanted LVAD in the 1960s, to the first FDA approved device in the early 2000s, to now the HM3 LVAD, with the most important change being a centrifugal flow/magnetically levitated design that led to minimized hemocompatibility-related adverse events (HRAEs) ( MOMENTUM 3 trial comparing HM2 and HM3 )

Conclusions and perspective Ever since it was isolated, A

2014), but two subsequent phase III trials (NCT02453386 and NCT03051607) were terminated due to an unexpected emerging safety issue