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Responding to the recommendation that the drug can only be prescribed for a maximum of two years, le Roux highlighted that five-year data would soon be available via the Semaglutide effects on heart disease and stroke in patients With overweight or obesity (SELECT) study

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Similarly, discontinuation of tirzepatide resulted in a substantial regain of lost weight in the SURMOUNT4 trial, with only 17% of the participants maintaining at least 80% of the weight loss achieved [7]

A subgroup of 2,856 individuals were evaluated for the effects of intensive vs

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