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MNs penetrate the stratum corneum and precisely deliver drugs to the subcutaneous WAT to induce its browning, exerting effective action at the target site, significantly reducing systemic side effects and improving therapeutic outcomes

Schauf M, Chinthapatla H, Dimri S, Li E, Hartung DM

REVI

The skin is a less efficient delivery route than subcutaneous fat

These bold experiments are offering an early glimpse of how the medications might work in real-world clinical settings

However, only 43% consumed at least 1.2 g/kg of protein, 10% consumed at least 1.6 g/kg, and 5% consumed at least 2.0 g/kg, calculated based on adjusted body weight