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Brain imaging studies have found similar changes in dopamine receptors, the neurotransmitter that creates a feeling of well-being and motivates us to repeat behaviors in people who overeat and use alcohol and drugs

Researchers found that patients who achieved the greatest reductions in body weight after starting GLP-1-based medications had substantially lower risks of conditions including obstructive sleep apnea, chronic kidney disease, osteoarthritis, and heart failure

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However, when mitochondria become damaged or depolarized due to oxidative stress or high glucose levels in DR, PINK1 accumulates on the outer mitochondrial membrane