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The researchers found that GLP-1 receptor agonist initiation was associated with a reduced risk for disorders related to alcohol use, cannabis use, cocaine use, nicotine use, opioid use, and other SUDs compared with initiation of SGLT-2 inhibitors (hazard ratios, 0.82, 0.86, 0.80, 0.80, 0.75, and 0.87, respectively) and with a reduced risk for the composite outcome of all incident SUDs (hazard ratio, 0.86)

This is a trial or microdosing size: a 5mg vial holds two and a half 2mg starting doses, so most people move to a larger vial once they tolerate treatment

External resources Subcutaneous Semaglutide during Breastfeeding: Infant Safety (PMC) GLP-1 Receptor Agonists During Pregnancy and Lactation (CMAJ/PMC) In case I do not see you, good afternoon, good evening, and good night

If you have these or related risks, you should steer clear of this drug

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43 In a phase 3 trial including patients with obesity (excluding T2DM), the highest dose group achieved a mean weight reduction of 11.2% by week 72
