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Medullary thyroid carcinoma (MTC) and MEN2 -- both drugs carry a boxed warning based on rodent thyroid C-cell tumors

Focus on: Calorie-dense but nutrient-dense foods: nut butters, avocados, protein shakes Liquid calories when solid food feels impossible: smoothies with protein powder, yogurt, and fruit Eating by the clock rather than by hunger signals (every 3-4 hours regardless of appetite) Prioritizing protein at every eating occasion Calorie target at 5-7.5mg: 1,200-1,500 for most people

Totsch SK, Meir RY, Quinn TL, Lopez SA, Gower BA, Sorge RE

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The KEGG pathway analysis indicated that TZP treatment led to the activation of the metabolismrelated pathways and those related to cancer, cell cycle, etc