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Description
Glucagon-like peptide-1 (GLP-1) is a gut-derived hormone that has received increasing attention in recent years

Clinical evidence on the involvement of gut-related factors in osteoporosis led us to undertake the core concept of the gutbone axis and systematically summarize that the intestinal intrinsic structure, gut microbiota, and derived metabolites, with the immune and endocrine routes as the intermediate transitions, attain a bidirectional interplay with skeletal tissue through the gutbone axis

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GLP-1 signaling appears to modulate corticotropin-releasing hormone (CRH) neurons in the hypothalamus

Semaglutide's blood-glucose-lowering effects create potential interactions with insulin, sulfonylureas, and certain cardiovascular medications that warrant careful provider oversight

They are small but efficient