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In treating diabetes, when constipation is an issue, I already switch between Ozempic, the older GLP-1 medicines Victoza and Trulicity, and the newer Mounjaro

Yes, you can eat pizza on Ozempic, but high-fat toppings may trigger nausea

In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

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Ozempic can be difficult to get and isn't appropriate for everyone

Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation