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This manifests as hepatic injury and inflammation in the liver and can range from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), also known as nonalcoholic steatohepatitis (NASH) (172, 173)

The estimated loss of skeletal muscle in these two major trials (10% or more during 6872 weeks of treatment) approximates the average decline in muscle mass during 20 years of agingrelated muscle loss in adults older than 30 years, estimated at 3%5% per decade (Figure 5)

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This feedback loop can reinforce itself if the underlying metabolic drivers are not addressed

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supply chain, he said