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"This suggests that it is primarily the amount of GLP-1 circulating in the body that determines how much reaches the joint." The study also detected DPP-4 (dipeptidyl peptidase-4), an enzyme that breaks down GLP-1, in synovial fluid a finding the authors note has implications for the design of any joint-targeted GLP-1 therapy, since a drug delivered directly into a joint would face enzymatic degradation

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Regarding patient-reported outcomes, ixekizumab plus tirzepatide bested ixekizumab alone as assessed by Health Assessment Questionnaire-Disability Index ( = 0.2

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These medications also require caution in people with a personal or family history of medullary thyroid cancer or MEN2, history of pancreatitis, significant gallbladder disease, severe gastroparesis, or active eating disorder concerns