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Tirzepatide (Mounjaro for diabetes and Zepbound for obesity, both Eli Lilly), a dual GLP-1/GIP agonist titrated gradually across a broad dosing range, showed a favorable safety profile, with GIP agonism probably buffering GLP-1-mediated fluid shifts, stabilizing vascular tone and reducing ischemic vulnerability

Plant-based dietary interventions, on the other hand, have led to significant weight loss along with improvements in cardiometabolic risk factors

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Hip and lumbar spine BMD were chosen as the main outcomes because they are the most frequently used sites in the clinical assessment of osteoporosis and are preferred for assessments of fracture risk and treatment response