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For patients researching GLP-1 weight loss, medical weight loss, semaglutide, or tirzepatide, the most important question is not simply, Which medication causes the most weight loss? A better question is: Which medically supervised approach is appropriate for my health history, body composition, metabolic risk, side-effect tolerance, and long-term maintenance plan

GLP-1 medications function similarly to a hormone that helps regulate appetite, digestion, and blood sugar levels

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It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case