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Although the genetic signal reaches clear statistical significancethe main association in GLP1R showed a P value of 2.9 10 and was externally replicated in All of Us (P = 0.001)the effect size remains modest, at around 0.76 kg of additional weight loss per allele for the lead variant

Concurrently, future clinical evidence is needed to estimate the GLP-1RA efficacy on CV outcomes, mortality, and allograft function

Approved Body Areas for Semaglutide Injection Semaglutide is delivered as a subcutaneous injection, meaning it goes into the fatty tissue just under your skin rather than into muscle or vein

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