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What separates high responders from moderate responders Post-hoc analyses of the SURMOUNT trials identified patterns in who responds most strongly to tirzepatide

Gastrointestinal effects (nausea, diarrhea) are common initially

But brand-name pricing through MEDVi reportedly reaches $1,999 per month, which is significantly higher than obtaining brand tirzepatide through other channels

For those who have already had cholecystectomy, the risk of gallbladder stones is eliminated, though bile duct stones (choledocholithiasis) can still occur, albeit less commonly

And the discontinuation rate due to adverse events runs roughly 2-3 times higher than tirzepatide at equivalent trial timepoints