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Tirzepatide achieves greater weight loss (up to 22.5 percent vs roughly 15 percent for semaglutide) and stronger insulin sensitization from added GIP activity, which may help cortisol-driven insulin resistance indirectly

[DOI] [PubMed] [Google Scholar] 84.Bouviere J., Fortunato R.S., Dupuy C., Werneck-de-Castro J.P., Carvalho D.P., Louzada R.A

Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors

The guide on how to wean off tirzepatide covers the tapering process in detail

GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake